Research interest: enzymology, toxicology, medicinal and bioinorganic chemistry; pharmacological properties of (novel) synthesized metal based compounds in the purpose of new drug development; interactions between the biologically active compounds and enzyme targets (cholinesterases and ATPases) in cancer and neurological diseases – experimental enzymatic and spectroscopic methods; in vitro prooxidative, cyto- and genotoxic effects on various isolated human and/or animal model cells; in vivo antidiabetic properties and toxicity evaluation by monitoring various biomarkers of nephro- and hepatotoxicity; cholinesterase based systems for detection and neurotoxicity evaluation of organophosphorous insecticides/degradation products
Education:
M.Sc. Graduate engineer of technology for biochemical engineering and biotechnology, University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia, 2004.
Ph.D. Chemistry and chemical technology, University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia, 2014. (Doctoral dissertation: “Bioanalytical methods for detection and toxicity evaluation of organo-thiophosphorous insecticides and their degradation products“)
Career:
University of Belgrade, “Vinča” Institute of Nuclear Sciences, Department of Physical Chemistry, Belgrade, Serbia, 2005-present
Active projects:
Program topic “Chemical-biological approach for the characterization of bioactive compounds – strategy for health and environmental advancement“, 2020 – present
Bilateral scientific collaboration Republic of Serbia – Public Republic of China, „Polyoxovanadates as promising anticancer drug candidates: modulation of Na+,K+-ATPase and ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) activity (POVaCan)”, pr. no. 451-02-818/2021-09/01, 2021-2023. (project leader)
List of five selected publications:
- M.B. Čolović, M. Lacković, J. Lalatović, A.S. Mougharbel, U. Kortz, D.Z. Krstić, Polyoxometalates in biomedicine: update and overview. Current Medicinal Chemistry, 2020, 27(3), 362-379. doi: 10.2174/0929867326666190827153532
- M.B. Čolović, B. Medić, M. Ćetković, T. Kravić Stevović, M. Stojanović, W.W. Ayass, A.S. Mougharbel, M. Radenković, M. Prostran, U. Kortz, D.Z. Krstić, Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity. Toxicology and Applied Pharmacology, 2017, 333, 68–75. http://dx.doi.org/10.1016/j.taap.2017.08.010
- M.B. Čolović, V.M. Vasić, N.S. Avramović, M.M. Gajić, D.M. Djurić, D.Z. Krstić, In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes. Toxicology Letters, 2015, 233(1), 29–37. https://doi.org/10.1016/j.toxlet.2015.01.003
- M.B. Čolović, D.Z. Krstić, T.D. Lazarević-Pašti, A.M. Bondžić, V.M. Vasić, Acetylcholinesterase inhibitors: pharmacology and toxicology. Current Neuropharmacology, 2013, 11(3), 315–335. https://doi.org/10.2174/1570159X11311030006
- M.B. Čolović, D.V. Bajuk-Bogdanović, N.S. Avramović, I.D. Holclajtner-Antunović, N.S. Bošnjaković-Pavlović, V.M. Vasić, D.Z. Krstić, Inhibition of rat synaptic membrane Na+/K+-ATPase and ecto-nucleoside triphosphate diphosphohydrolases by 12-tungstosilicic and 12-tungstophosphoric acid. Bioorganic & Medicinal Chemistry, 2011, 19(23), 7063-7069. https://doi.org/10.1016/j.bmc.2011.10.008